Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study

BMJ 2017;358:j3668

This population based cohort study aims to investigate the association between in utero exposure to antidepressants and risk of psychiatric disorders.  905 383 liveborn singletons born during 1998-2012 in Denmark were followed from birth until July 2014, death, emigration, or date of first psychiatric diagnosis, whichever came first. The children were followed for a maximum of 16.5 years and contributed 8.1×106 person years at risk. The study concludes that in utero exposure to antidepressants was associated with increased risk of psychiatric disorders. The association may be attributable to the severity of underlying maternal disorders in combination with antidepressant exposure in utero. The findings suggest that focusing solely on a single psychiatric disorder among offspring in studies of in utero antidepressant exposure may be too restrictive.

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