The Lancet, 21 February 2018
This systematic review and network meta-analysis aims to update and expand previous work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder. The review included placebo-controlled and head-to-head trials of 21 antidepressants used for the acute treatment of adults (≥18 years old and of both sexes) with major depressive disorder diagnosed according to standard operationalised criteria. The study concludes that all antidepressants were more efficacious than placebo in adults with major depressive disorder. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy and acceptability in head-to-head trials.
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Cochrane Database of Systematic Reviews, November 2017
This Cochrane Review finds that music therapy plus treatment as usual is more effective than treatment as usual alone. Music therapy seems to reduce depressive symptoms and anxiety and helps to improve functioning (e.g. maintaining involvement in job, activities, and relationships).
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