Lancashire Care Library and Information Service
BMJ, 23 November 2015
This randomised controlled trial seeks to establish whether stepped care compared with usual care is effective in preventing the onset of major depressive, dysthymic, and anxiety disorders in older people with visual impairment (caused mainly by age related eye disease) and subthreshold depression and/or anxiety.
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BMJ, 11 November 2015
This study assesses the effectiveness of supported computerised cognitive behaviour therapy (cCBT) as an adjunct to usual primary care for adults with depression.
The study concludes that supported cCBT does not substantially improve depression outcomes compared with usual GP care alone. In this study, neither a commercially available nor free to use computerised CBT intervention was superior to usual GP care.
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BMJ, 16 September 2015
The aim of this study is to reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The reanalysis under the restoring invisible and abandoned trials (RIAT) initiative was done to see whether access to and reanalysis of a full dataset from a randomised controlled trial would have clinically relevant implications for evidence based medicine.
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