Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study

BMJ 2017;358:j3668

This population based cohort study aims to investigate the association between in utero exposure to antidepressants and risk of psychiatric disorders.  905 383 liveborn singletons born during 1998-2012 in Denmark were followed from birth until July 2014, death, emigration, or date of first psychiatric diagnosis, whichever came first. The children were followed for a maximum of 16.5 years and contributed 8.1×106 person years at risk. The study concludes that in utero exposure to antidepressants was associated with increased risk of psychiatric disorders. The association may be attributable to the severity of underlying maternal disorders in combination with antidepressant exposure in utero. The findings suggest that focusing solely on a single psychiatric disorder among offspring in studies of in utero antidepressant exposure may be too restrictive.

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Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study

BMJ 2017;358:j3326

This observational cohort study aims to assess the impact of in utero co-exposure to psychotropic medications and opioids on the incidence and severity of neonatal drug withdrawal.  The study concludes that during pregnancy, the use of psychotropic medications in addition to prescription opioids is common, despite a lack of safety data. The current findings suggest that these drugs could further increase the risk and severity of neonatal drug withdrawal.

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