Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU)

BMJ 2017;359:j5157

This randomized controlled trial aims to determine the effect of low dose aspirin on ulcer healing in patients with venous leg ulcers.  The participants included 251 adults with venous leg ulcers who could safely be treated with aspirin or placebo: 125 were randomised to aspirin and 126 to placebo.  The conclusion of the study suggests that the findings do not support the use of low dose aspirin as adjuvant treatment for venous leg ulcers.

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Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis

BMJ 2017;359:j5375

This study aims to determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer’s disease.  The design of the study is a Mendelian randomisation study using genetic variants associated with the modifiable risk factors as instrumental variables.  The study concludes that the results provide support that higher educational attainment is associated with a reduced risk of Alzheimer’s disease.

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A framework for mental health research

Department of Health, December 2017

This framework provides a collective view of how mental health research should develop in the UK over the next decade. It sets out a structure to improve co-ordination and strengthen the focus on areas where mental health research is likely to translate into significant health benefit.

Click here to view the guidance.

Mental ill-health among children of the new century

UCL Institute of Education, September 2017

Researchers from the UCL Institute of Education and the University of Liverpool analysed information on more than 10,000 children born in 2000-01 who are taking part in the Millennium Cohort Study. At ages 3, 5, 7, 11 and 14, parents reported on their children’s mental health. Then, when they reached 14, the children were themselves asked questions about their depressive symptoms. a quarter of girls (24%) and one in 10 boys (9%) are depressed at age 14.

Click here to view the full report.

The Obsessive Compulsive Treatment Efficacy randomised controlled Trial (OCTET)

NIHR, September 2017

This NIHR-funded trial included 473 adults with moderate to severe obsessive-compulsive disorder who were already waiting to receive CBT. It found that offering people book-based or computer-based CBT whilst on a waiting list for therapist-led therapy did not improve their obsessive-compulsive symptoms when assessed after three or 12 months.

Click here to access the NIHR Signal.

Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials

BMJ 2017;358:j3927

This systematic review and meta-analyses of relapse prevention trials aims to examine the risk of relapse and time to relapse after discontinuation of antidepressants in patients with anxiety disorder who responded to antidepressants, and to explore whether relapse risk is related to type of anxiety disorder, type of antidepressant, mode of discontinuation, duration of treatment and follow-up, comorbidity, and allowance of psychotherapy.

Click here to view the full text paper.