Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials

BMJ 2017;358:j3927

This systematic review and meta-analyses of relapse prevention trials aims to examine the risk of relapse and time to relapse after discontinuation of antidepressants in patients with anxiety disorder who responded to antidepressants, and to explore whether relapse risk is related to type of anxiety disorder, type of antidepressant, mode of discontinuation, duration of treatment and follow-up, comorbidity, and allowance of psychotherapy.

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Honoring the voices of bereaved caregivers: a Metasummary of qualitative research

BMC Palliative Care, September 2017

Family caregiving in the context of advanced disease in particular, can be physically and emotionally taxing. Caregivers can subsequently face bereavement exhausted with few supports, limited resources and a significant proportion will develop negative psychological and social outcomes. Although some research has attended to the bereavement experiences of family caregivers who had cared for a person requiring palliative care, a comprehensive qualitative understanding of the impact of caregiving on bereavement has not been articulated. The purpose of this study was to conduct a qualitative metasummary to explore the experiences of bereaved family caregivers of people who received palliative care services, regardless of their underlying disease.

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Dementia prevention, intervention, and care

The Lancet, July 2017

Dementia is the greatest global challenge for health and social care in the 21st century: around 50 million people worldwide have dementia and this number is predicted to triple by 2050. The Lancet Commission on dementia aims to review the best available evidence and produce recommendations on how to best manage, or even prevent, the dementia epidemic.

Dementia is not an inevitable consequence of ageing and the Commission identifies nine potentially modifiable health and lifestyle factors from different phases of life that, if eliminated, might prevent dementia. Although therapies are currently not available to modify the underlying disease process, the Commission outlines pharmacological and social interventions that are able to help manage the manifestations of dementia.

Click here to request this report from the Library.

Case report: Brief Trans-diagnostic CBT for Distressed Carers of Service User with First Episode Psychosis Distress

Miv Riley, Lancashire Care NHS Foundation Trust

Congratulations to Miv Riley who has recently presented a poster at the BABCP Conference in Madrid on a case report of using brief trans-diagnostic CBT to help a distressed carer of an individual with first episode psychosis.

Click here to request a copy of the conference abstract from the Library.

Health Research Authority eLearning modules

Health Research Authority, July 2017

The HRA have developed six new eLearning modules as an aid for researchers, R&D staff, study sponsors, research ethics committee members and the wider research community. The modules are relevant to all four nations of the UK and cover key areas of research regulation, helping to protect and promote the interests of patients and the public in health and care research.

The first three topics to be released are: medical devices, research involving participants lacking mental capacity, and use of the HRA Schedule of Events. Three further modules concerning research involving human tissue, research involving exposure to ionising radiation and confidentiality and information governance considerations in research, are to be released imminently.

Click here to access the modules.

Temporal trend in dementia incidence since 2002 and projections for prevalence in England and Wales to 2040: modelling study

BMJ 2017;358:j2856

This modelling study aims to forecast dementia prevalence with a dynamic modelling approach that integrates calendar trends in dementia incidence with those for mortality and cardiovascular disease.  Age specific dementia incidence is declining. The number of people with dementia in England and Wales is likely to increase by 57% from 2016 to 2040. This increase is mainly driven by improved life expectancy.

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