Lancashire Care Research Bulletin – May 2018

Lancashire Care Library and Information Service, May 2018

Please click here to view the latest Lancashire Care Research bulletin to see research and journal articles produced by staff in the Trust.

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Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study

BMJ 2018;360:k1218

This cohort study aims to compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction.

The results of the study suggest a small increased risk of death within seven days of initiating haloperidol compared with initiating an atypical antipsychotic in patients with acute myocardial infarction. Although residual confounding cannot be excluded, this finding deserves consideration when haloperidol is used for patients admitted to hospital with cardiac morbidity.

Click here to access this paper.

Forward thinking: NIHR research on support for people with severe mental illness

National Institute of Health Research, March 2018

Report from the National Institute of Health Research detailing 30 published studies funded by the National Institute of Health Research (NIHR) and additional examples of ongoing research that  provides an overview of recent research funded by the NIHR on the support for people living with severe mental illness.  The focus of research is on:

  • Support early detection and intervention
  • Focus on crisis care in terms of location, settings and practice
  • Stabilising, managing mental and physical health

Supporting recovery, self management and engagement.

Click here to view the full report.

Impact of person-centred care training and person-centred activities on quality of life, agitation, and antipsychotic use in people with dementia living in nursing homes: A cluster-randomised controlled trial

PLOS Medicine, February 6, 2018

This study aimed to evaluate the efficacy of a person-centred care and psychosocial intervention incorporating an antipsychotic review, WHELD, on QoL, agitation, and antipsychotic use in people with dementia living in nursing homes, and to determine its cost.

Click here to view the paper.

Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU)

BMJ 2017;359:j5157

This randomized controlled trial aims to determine the effect of low dose aspirin on ulcer healing in patients with venous leg ulcers.  The participants included 251 adults with venous leg ulcers who could safely be treated with aspirin or placebo: 125 were randomised to aspirin and 126 to placebo.  The conclusion of the study suggests that the findings do not support the use of low dose aspirin as adjuvant treatment for venous leg ulcers.

Click here to view the full text paper.

Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis

BMJ 2017;359:j5375

This study aims to determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer’s disease.  The design of the study is a Mendelian randomisation study using genetic variants associated with the modifiable risk factors as instrumental variables.  The study concludes that the results provide support that higher educational attainment is associated with a reduced risk of Alzheimer’s disease.

Click here to read the full text paper.