Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

Brain, awz099, https://doi.org/10.1093/brain/awz099

This study describes a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE shares similar symptoms to Alzheimer’s disease, but it is a distinct disease linked to different brain proteins.  Interventions designed for Alzheimer’s disease will therefore be ineffective for LATE.  Developing an understanding of LATE will hopefully lead to new avenues of research into dementia treatments and care.

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The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

The Lancet Psychiatry, 19 March 2019

This large multicentre case-control study conducted across 11 sites in Europe and Brazil found that daily cannabis use was associated with increased odds of psychotic disorder compared with people who had never used cannabis, increasing to nearly five-times increased odds for daily use of high-potency types of cannabis.

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Improving patient safety through collaboration: a rapid review of the academic health science networks’ patient safety collaboratives

The ASHN Network, March 2019

This report discusses the progress and impact made by England’s Patient Safety Collaboratives (PSCs) in their first four years. It was commissioned by The AHSN Network and written by The King’s Fund. The report notes how interest is shifting from supporting the improvement of individual services to improving how different services work together in local systems. It highlights the role the PSC programme has had in creating a movement for change and cultivating a shared vision among health and care organisations. It also suggests some areas PSCs and national NHS bodies could focus on to further support innovation, quality improvement and patient safety.

Click here to view the full report.

Involving NHS staff in research

Healthcare Improvement Studies Institute, February 2019

This report looks at the different ways NHS staff are getting involved in the research process including designing studies, collecting data, and disseminating and implementing research findings.  It also looks at how staff involvement in research could be improved and describes some of the barriers to active involvement, from lack funding and support through to a tendency for research opportunities to be offered to certain healthcare professions and specialties.

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Intellectual engagement and cognitive ability in later life (the “use it or lose it” conjecture): longitudinal, prospective study

BMJ 2018;363:k4925

This longitudinal, prospective, observational study aims to examine the association between intellectual engagement and cognitive ability in later life, and determine whether the maintenance of intellectual engagement will offset age related cognitive decline.  The study concludes that self reported engagement is not associated with the trajectory of cognitive decline in late life, but is associated with the acquisition of ability during the life course. Overall, findings suggest that high performing adults engage and those that engage more being protected from relative decline.

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