This cohort study aims to compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction.
The results of the study suggest a small increased risk of death within seven days of initiating haloperidol compared with initiating an atypical antipsychotic in patients with acute myocardial infarction. Although residual confounding cannot be excluded, this finding deserves consideration when haloperidol is used for patients admitted to hospital with cardiac morbidity.
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National Institute of Health Research, March 2018
Report from the National Institute of Health Research detailing 30 published studies funded by the National Institute of Health Research (NIHR) and additional examples of ongoing research that provides an overview of recent research funded by the NIHR on the support for people living with severe mental illness. The focus of research is on:
- Support early detection and intervention
- Focus on crisis care in terms of location, settings and practice
- Stabilising, managing mental and physical health
Supporting recovery, self management and engagement.
Click here to view the full report.
Click here to view the February edition of the LCFT Research bulletin featuring research and journal articles produced by Lancashire Care staff.
PLOS Medicine, February 6, 2018
This study aimed to evaluate the efficacy of a person-centred care and psychosocial intervention incorporating an antipsychotic review, WHELD, on QoL, agitation, and antipsychotic use in people with dementia living in nursing homes, and to determine its cost.
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This randomized controlled trial aims to determine the effect of low dose aspirin on ulcer healing in patients with venous leg ulcers. The participants included 251 adults with venous leg ulcers who could safely be treated with aspirin or placebo: 125 were randomised to aspirin and 126 to placebo. The conclusion of the study suggests that the findings do not support the use of low dose aspirin as adjuvant treatment for venous leg ulcers.
Click here to view the full text paper.
This study aims to determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer’s disease. The design of the study is a Mendelian randomisation study using genetic variants associated with the modifiable risk factors as instrumental variables. The study concludes that the results provide support that higher educational attainment is associated with a reduced risk of Alzheimer’s disease.
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Department of Health, December 2017
This framework provides a collective view of how mental health research should develop in the UK over the next decade. It sets out a structure to improve co-ordination and strengthen the focus on areas where mental health research is likely to translate into significant health benefit.
Click here to view the guidance.