Five years of specialised early intervention versus two years of specialised early intervention followed by three years of standard treatment for patients with a first episode psychosis: randomised, superiority, parallel group trial in Denmark (OPUS II)

BMJ 2017;356:i6681 – January 2017

This randomised, superiority, parallel group trial aims to compare the effects of five years of specialised early intervention (SEI) treatment for first episode schizophrenia spectrum disorder with the standard two years of SEI plus three years of treatment as usual.

Click here to access the full text paper.

 

Advertisements

Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial

The Lancet, October 2016

This is a randomised controlled trial of a parent-mediated social communication intervention for children aged 2–4 years with core autism to investigate whether early intervention can improve long-term autism symptom outcomes.  The results are the first to show long-term symptom reduction after a randomised controlled trial of early intervention in autism spectrum disorder. They support the clinical value of the PACT intervention and have implications for developmental theory.

Click here to view the full text paper.

Clinical effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia: A multicentre randomised controlled trial

NIHR Health Technology Assessment programme, February 2016

The negative symptoms of schizophrenia significantly impact on quality of life and social functioning, and current treatment options are limited. In this study the clinical effectiveness and cost-effectiveness of group body psychotherapy as a treatment for negative symptoms were compared with an active control.

Click here for more information and to download the full text article.

A zero cost way to reduce missed hospital appointments

Department of Health, January 2016

This randomised controlled trial tested the effectiveness of the reminder message sent to outpatients. Results showed if the message included the specific cost to the NHS of not attending then the patient was more likely to attend or rearrange their appointment – rather than miss it.

Click here for a summary of the research.

Stepped care for depression and anxiety in visually impaired older adults: multicentre randomised controlled trial

BMJ, 23 November 2015

This randomised controlled trial seeks to establish whether stepped care compared with usual care is effective in preventing the onset of major depressive, dysthymic, and anxiety disorders in older people with visual impairment (caused mainly by age related eye disease) and subthreshold depression and/or anxiety.

Click here to read the full text.

Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial

BMJ, 11 November 2015

This study assesses the effectiveness of supported computerised cognitive behaviour therapy (cCBT) as an adjunct to usual primary care for adults with depression.

The study concludes that supported cCBT does not substantially improve depression outcomes compared with usual GP care alone. In this study, neither a commercially available nor free to use computerised CBT intervention was superior to usual GP care.

Click here to access the full text paper.

Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence

BMJ, 16 September 2015

The aim of this study is to reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The reanalysis under the restoring invisible and abandoned trials (RIAT) initiative was done to see whether access to and reanalysis of a full dataset from a randomised controlled trial would have clinically relevant implications for evidence based medicine.

Click here to view the full text paper.