Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study

BMJ, 6 January 2016

This prospective cohort study aims to research whether oral contraceptive use around the time of pregnancy onset is associated with an increased risk of major birth defects?

The study finds that oral contraceptive exposure just before or during pregnancy does not appear to be associated with an increased risk of major birth defects.

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Beverage purchases from stores in Mexico under the excise tax on sugar sweetened beverages: observational study

BMJ, 6 January 2016

This study looks at the effect on purchases of beverages from stores in Mexico one year after implementation of the excise tax on sugar sweetened beverages.

The study finds that the tax on sugar sweetened beverages was associated with reductions in purchases of taxed beverages and increases in purchases of untaxed beverages. Continued monitoring is needed to understand purchases longer term, potential substitutions, and health implications.

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Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials

BMJ, 25 November 2015

This systematic review looks at whether methylphenidate is beneficial or harmful for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents?

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Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study

BMJ, 11 November 2015

This prospective cohort study looks at whether it is possible to develop and externally validate risk prediction equations to estimate the 10 year risk of blindness and lower limb amputation in patients with diabetes aged 25-84 years.

The study concludes that patients with type 1 or type 2 diabetes are at increased risk of blindness and amputation but generally do not have accurate assessments of the magnitude of their individual risks. The new algorithms calculate the absolute risk of developing these complications over a 10 year period in patients with diabetes, taking account of their individual risk factors.

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Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial

BMJ, 11 November 2015

This study assesses the effectiveness of supported computerised cognitive behaviour therapy (cCBT) as an adjunct to usual primary care for adults with depression.

The study concludes that supported cCBT does not substantially improve depression outcomes compared with usual GP care alone. In this study, neither a commercially available nor free to use computerised CBT intervention was superior to usual GP care.

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